Seizure Frequency and EEG Abnormalities in Children with Autism: A Comparative Study of with and without Regression

Abstract

Background: Regression in children with autism spectrum disorder (ASD) may reflect distinct underlying neurobiological mechanisms. Understanding neurophysiological and neurochemical differences is crucial for refining diagnosis and intervention. Methods: This study compared auditory brainstem responses (ABR), gamma band power, and serum levels of GABA and glutamate in two groups of children with ASD—those with regression and those without. Results: Children with regression exhibited significantly higher gamma power and lower GABA levels than those without regression. ABR latencies also differed between the groups, suggesting variations in auditory processing. Conclusions: The findings highlight potential neurophysiological and neurochemical markers differentiating regressive from non-regressive ASD. These results may inform future diagnostic tools and individualized treatment strategies.