Prevalence of Depression in Patients with Chronic Kidney Disease on Hemodialysis and Its Impact on the Quality of Life

Abstract

Background: Depression is the most common co-morbid psychiatric condition in patients with chronic kidney disease (CKD) undergoing maintenance hemodialysis. The aim of the present study was to evaluate the prevalence of depression in patients with chronic kidney disease undergoing hemodialysis and its impact on the quality of life. Materials and Methods: Cross sectional assessment of 105 patients using Mini International Neuropsychiatric Interview (MINI-6), Kidney Disease Quality of Life Short Form (KDQOL-SF) was done over a period of one year duration. Results: The mean age of patients undergoing hemodialysis was 51.29 ± 15.26 years. Males (76.2%) outnumbered females in the study population. About 99% of the patients had co-morbid hypertension and 48.5% had co-morbid diabetes mellitus. Major depressive disorder was present in 25.7% with significant bio-socio-occupational dysfunction. Patients with long standing hypertension were significantly more in patients with major depressive disorders in the study sample. In addition, patients with major depressive disorder had poor quality of life with significance in cognitive function, quality of social interaction, social functioning and pain. Conclusion: The present study found one in four patients with CKD on hemodialysis has depressive disorder and was associated with patients with longer duration of comorbid hypertension. Patients with depression had higher impartment in the quality of life.